There may be an upside to allergies and asthma; protection against skin cancer

Scientists at Washington University School of Medicine in St. Louis have discovered a molecule involved in asthma and allergies that seems to make mice resistant to skin cancer.

The molecule, called TSLP (thymic stromal lymphopoietin), is produced by damaged skin and activates the immune system. Chronic low levels of TSLP are suspected in making the immune system oversensitive to what should be a harmless environment, leading to the skin rashes and overproduction of mucus common in allergies and asthma.

“But at extremely high levels, TSLP appears to train the immune system to recognize skin cancer cells, and target those cells for elimination,” says Raphael Kopan, PhD, the Alan A. and Edith L. Wolff Professor of Developmental Biology. “These experiments demonstrate that there is a way for a natural molecule to help immune cells recognize and reject tumors, at least in the skin.”

The study appears online Oct 15 in Cancer Cell.

These findings are surprising because most current evidence suggests that the allergic inflammation and release of TSLP increases — not decreases — the risk of tumor development.

The disparity may be explained by the amount of TSLP that is produced. The mice that were resistant to skin tumor growth had blood levels of TSLP that were 1,000-fold higher than normal. And levels in the skin — where it is made — may be even higher.

“This is an example of where hyper-vigilance of the immune system may end up paying dividends,” Kopan says. “Not only does it respond aggressively to an innocuous allergen, but it begins to monitor, survey and destroy cells that are mutant.”

The results are supported by another study in the same issue of Cancer Cell also showing TSLP prevents skin cancer in mice.

Researchers discover link between radon and skin cancer

The indoor air quality in many North American homes
is affected by radon and other contaminants.

Radon, the naturally occurring radioactive gas that can build up in people’s homes, has been identified as a leading cause of lung cancer before – and now a study shows it may also have other health effects.

A new study suggests that a link may exist between radon exposure and non-melanoma skin cancer.

Researchers from the European Centre for Environment & Human Health (part of the Peninsula College of Medicine & Dentistry) have detected a connection following analysis of data on radon exposure and skin cancer cases from across southwest England.

The link was not evident in the development of malignant melanoma, the most common form of skin cancer, but it was found between areas where high radon concentrations are found and a particular type of non-melanoma skin cancer called squamous cell carcinoma.

"We know that naturally occurring radon is a contributing factor to a small proportion of lung cancers, but there is limited evidence of other health implications,” says the study’s lead author Dr. Ben Wheeler.

“These findings suggest that the issue of radon and skin cancer deserves a much closer look and we're planning to develop a more detailed study capable of detecting a direct relationship, if one actually exists.”

Health effects of radon exposure

Radon exposure has been linked to
lung cancer and now skin cancer.

EPA estimates that about 20,000 lung cancer deaths each year in the U.S. are radon-related.  Exposure to radon is the second leading cause of lung cancer after smoking. 

According to EPA, two studies show definitive evidence of an association between residential radon exposure and lung cancer.

“These findings effectively end any doubts about the risks to Americans of having radon in their homes,” said Tom Kelly, Former Director of EPA’s Indoor Environments Division.  “We know that radon is a carcinogen.  This research confirms that breathing low levels of radon can lead to lung cancer.”

EPA recommends homes be fixed if the radon level is 4 pCi/L (pico Curies per Liter) or more. Because there is no known safe level of exposure to radon, EPA also recommends that Americans consider fixing their home for radon levels between 2 pCi/L and 4 pCi/L.

Indoor air quality at home

Radon is just one of many contaminants that can lead to poor indoor air quality and health effects.

Most North American homes, especially those with airtight construction and poor ventilation, suffer from indoor air contaminants such as chemicals and gases (like VOCs from cleaning agents, fragrances and building materials), particles and dust, mold, bacteria and viruses.

Using low-VOC products, natural cleaning agents and increasing ventilation all help to improve indoor air quality, but another easy and effective solution is a powerful home or office air purifier with activated carbon + HEPA.

AllerAir air purifiers

AllerAir’s portable air purifiers can remove the widest range of pollutants with its multistage filtration system.

The deep-bed activated carbon filter removes many gases, odors, chemicals and fumes, while the medical-grade or micro-HEPA traps tiny particles and pathogens. Pre-filters take care of larger particles and dust and protect the other filters’ lifespan.

For general purpose air purifiers or specialized units like MCS, Allergy and Asthma, Odor and Chemical Control, Mold and Tobacco Smoke, visit our website or contact AllerAir directly: 888-852-8247.