Women use more than 160 chemicals each day, group warns

Authorities should review five chemicals commonly used in
personal care products, two senators say.

American women put an average of 168 chemicals on their bodies each day, according to a nonprofit group, but two senators say federal regulations on personal care products have barely changed since the 1930s.

Senators Dianne Feinstein, D-California, and Susan Collins, R-Maine, introduced an amendment to the federal Food, Drug and Cosmetic Act that would give the Food and Drug Administration more power and oversight to regulate the chemicals men and women slather on their bodies every day.

They're calling it the Personal Care Products Safety Act.

"From shampoo to lotion, the use of personal care products is widespread, however, there are very few protections in place to ensure their safety," Feinstein said in a statement.

The 98-page bill includes a system of registering personal care companies, their products and their ingredients, and it would require the FDA to review five chemicals that appear generally in personal care products each year to evaluate their safety.

The first set of chemicals will likely be diazolidinyl urea, lead acetate, methylene glycol/formaldehyde, propyl paraben, quaternium-15, according to Feinstein’s office.

The senators worked with the Environmental Working Group, a nonprofit consumer health advocacy group that started the Skin Deep database about a decade ago.

Personal care products are not
regulated to ensure safety: Experts

The Skin Deep database allows consumers to look up personal care products to learn what chemicals they contain, and whether those chemicals are associated with any health risks.

"These are basic tools that should have been granted to the FDA decades ago, but are only now being provided in the Feinstein-Collins bill," said Scott Faber, Environmental Working Group's vice president of government affairs.

"Cosmetics are sort of the last unregulated area of consumer products law. I can't overstate how little law is now on the books. The FDA virtually has no power to regulate the products we use everyday."

According to the Environmental Working Group, women use an average of 12 products a day, containing 168 different chemicals.

Men use fewer products, but still put 85 chemicals on their bodies. Teens on average use 17 personal care products a day, according to the group, which tested 20 teens' blood and urine seven years ago to find out which chemicals from these products were ending up in their bodies.

They said they found 16 hormone-altering chemicals, including parabens and phthalates.

"Many if not most of these chemicals are probably safe," Faber said. "We can't know for sure because they haven't been subject to any kind of review by a third party."

Faber said attempts to give the FDA more authority over cosmetics date back to the Eisenhower administration, but they were unsuccessful.

This time, industry leaders including Johnson and Johnson, Revlon and Personal Care Products Council, the industry trade group, have come out to say they support the bill.

"While we believe our products are the safest category that FDA regulates, we also believe well-crafted, science-based reforms will enhance industry's ability to innovate and further strengthen consumer confidence in the products they trust and use every day," the Personal Care Products Council said in a statement.

"The current patchwork regulatory approach with varying state bills does not achieve this goal."

The FDA said it cannot comment on proposed legislation.

Source: ABC News

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Common solvents disrupt hormone systems, scientists warn

Benzene, xylene and other solvents contaminate the home

Low-level, everyday exposures to dangerous
chemicals are linked to many health issues,
scientists say.

Four chemicals present both inside and outside homes might disrupt our endocrine systems at levels considered safe by the U.S. Environmental Protection Agency, according to an analysis.

The chemicals – benzene, toluene, ethylbenzene and xylene – are ubiquitous: in the air outside and in many products inside homes and businesses. They have been linked to reproductive, respiratory and heart problems, as well as smaller babies.

Now researchers from The Endocrine Disruption Exchange (TEDX) and the University of Colorado, Boulder, say that such health impacts may be due to the chemicals’ ability to interfere with people’s hormones at low exposure levels.

“There’s evidence of connection between the low level, everyday exposures and things like asthma, reduced fetal growth,” said Ashley Bolden, a research associate at TEDX and lead author of the study.

“And for a lot of the health effects found, we think it’s disrupted endocrine-signaling pathways involved in these outcomes.”

Bolden and colleagues – including scientist, activist, author and TEDX founder Theo Colborn who passed away last December – pored over more than 40 studies on the health impacts of low exposure to the chemicals.

They looked at exposures lower than the U.S. Environmental Protection Agency’s reference concentrations for the chemicals, which is the agency’s estimated inhalation exposure level that is not likely to cause health impacts during a person’s lifetime.

Many of the health problems – asthma, low birth weights, cardiovascular, disease, preterm births, abnormal sperm – can be rooted in early disruptions to the developing endocrine system, Bolden said.

The analysis doesn’t prove that exposure to low levels of the chemicals disrupt hormones. However, any potential problems with developing hormone systems are cause for concern.

“Hormones are how the body communicates with itself to get work done. Interrupt that, you can expect all sorts of negative health outcomes,” said Susan Nagel an associate professor at the University of Missouri-Columbia Obstetrics, Gynecology and Women's Health School of Medicine who was not involved in the study.

Cathy Milbourn, a spokesperson for the EPA, said in an emailed response that the agency will "review the study and incorporate the findings into our work as appropriate."

The "EPA is screening thousands of chemicals for potential risk of endocrine disruption," she said. "As potential risk of endocrine disruption is identified, these chemicals are assessed further."

Chemicals found in many consumer products

The four chemicals are retrieved from the wellheads during crude oil and natural gas extraction and, after refining, are used as gasoline additives and in a wide variety of consumer products such as adhesives, detergents, degreasers, dyes, pesticides, polishes and solvents.

Ethylbenzene is one of the top ten chemicals used in children’s products such as toys and playground equipment, according to a 2013 EPA report.

Toluene is in the top ten chemicals used in consumer products such as fuels and paints, the report found.

All four get into indoor and outdoor air via fossil fuel burning, vehicle emissions and by volatizing from products. Bolden said studies that measure the air in and around homes and businesses find the chemicals 90 to 95 percent of the time.

Katie Brown, spokeswoman for Energy in Depth, a program of the Independent Petroleum Association of America, said in an email that the study suggests “products deemed safe by the U.S. Consumer Product Safety Commission are more dangerous than oil and gas development.

“Contrary to their intentions, what this report actually shows is that people should be no more afraid of oil and gas development than products in their home,” she said.

The Consumer Specialty Products Association, a trade group that represents companies that manufacturer consumer goods including cleaning products, pesticides, polishes, would not comment on the study but a spokesperson said that member groups typically don’t use the chemicals mentioned.

In several of the monitoring studies Bolden and colleagues examined, levels of the chemicals were higher in indoor air than in outdoor air, suggesting that people might be exposed within their homes.

“A lot of time indoor air is poorly circulated,” Bolden said.

Nagel cited a “huge need” to look at the impact of exposure to ambient levels of these chemicals. The study highlights “a whole lot we don’t know” about how these compounds may impact humans, she said.

Using human tissue cells, Nagel’s lab has previously shown that the chemicals can disrupt the androgen and estrogen hormones.

The authors said regulators should give air contaminants the same attention they’ve given greenhouse gas emissions recently.

“Tremendous efforts have led to the development of successful regulations focused on controlling greenhouse gases in an attempt to reduce global temperatures,” the authors wrote in the study published in Environmental Science and Technology journal.

“Similar efforts need to be directed toward compounds that cause poor air quality both indoors and outdoors.”

Source: Environmental Health News

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Hormone-disrupting activity of fracking chemicals worse than initially found

Many chemicals used in hydraulic fracturing, or fracking, can disrupt not only the human body's reproductive hormones but also the glucocorticoid and thyroid hormone receptors, which are necessary to maintain good health, a new study finds.

"Among the chemicals that the fracking industry has reported using most often, all 24 that we have tested block the activity of one or more important hormone receptors," said study author, Christopher Kassotis, a PhD student at the University of Missouri, Columbia. "The high levels of hormone disruption by endocrine-disrupting chemicals (EDCs) that we measured, have been associated with many poor health outcomes, such as infertility, cancer and birth defects."

Hydraulic fracturing is the process of injecting numerous chemicals and millions of gallons of water deep underground under high pressure to fracture hard rock and release trapped natural gas and oil. Kassotis said spills of wastewater could contaminate surface and ground water.

In earlier research, this group found that water samples collected from sites with documented fracking spills in Garfield County, Colorado, had moderate to high levels of EDC activity that mimicked or blocked the effects of the female hormones (estrogens) and the male hormones (androgens) in human cells. However, water in areas away from these gas-drilling sites showed little EDC activity on these two reproductive hormones.

The new study extended the analysis to learn whether high-use fracking chemicals changed other key hormone receptors besides the estrogen and androgen receptors. (Receptors are proteins in cells that the hormone binds to in order to perform its function.) Specifically, the researchers also looked at the receptor for a female reproductive hormone, progesterone, as well as those for glucocorticoid—a hormone important to the immune system, which also plays a role in reproduction and fertility—and for thyroid hormone. The latter hormone helps control metabolism, normal brain development and other functions needed for good health.

Among 24 common fracking chemicals that Kassotis and his colleagues repeatedly tested for EDC activity in human cells, 20 blocked the estrogen receptor, preventing estrogen from binding to the receptor and being able to have its natural biological response, he reported. In addition, 17 chemicals inhibited the androgen receptor, 10 hindered the progesterone receptor, 10 blocked the glucocorticoid receptor and 7 inhibited the thyroid hormone receptor.

Kassotis cautioned that they have not measured these chemicals in local water samples, and it is likely that the high chemical concentrations tested would not show up in drinking water near drilling. However, he said mixtures of these chemicals act together to make their hormone-disrupting effects worse than any one chemical alone, and tested drinking water normally contains mixtures of EDCs.

"We don't know what the adverse health consequences might be in humans and animals exposed to these chemicals," Kassotis said, "but infants and children would be most vulnerable because they are smaller, and infants lack the ability to break down these chemicals."

What percentage of your food has some type of packaging? It may be making you sick.

photo: antpkr/freedigitalphotos.net

Think of your last trip to the grocery store -- it's likely that even your vegetables may be housed in some type of packaging. 

Scientists are now concerned that all those synthetic chemicals used in the packaging, storage, and processing of foodstuffs might be harmful to human health over the long term.

In a commentary in the Journal of Epidemiology and Community Health, the researchers say that most of these substances are not inert and can leach into the foods we eat.

Despite the fact that some of these chemicals are regulated, people who eat packaged or processed foods are likely to be chronically exposed to low levels of these substances throughout their lives, say the authors.

And far too little is known about their long term impact, including at crucial stages of human development, such as in the womb, which is "surely not justified on scientific grounds," the authors claim.

They point out that lifelong exposure to food contact materials or FCMs - substances used in packaging, storage, processing, or preparation equipment - "is a cause for concern for several reasons."

These include the fact that known toxicants, such as formaldehyde, a cancer causing substance, are legally used in these materials. Formaldehyde is widely present, albeit at low levels, in plastic bottles used for fizzy drinks and melamine tableware.

Secondly, other chemicals known to disrupt hormone production also crop up in FCMs, including bisphenol A, tributyltin, triclosan, and phthalates.

"Whereas the science for some of these substances is being debated and policy makers struggle to satisfy the needs of stakeholders, consumers remain exposed to these chemicals daily, mostly unknowingly," the authors point out.

And, thirdly, the total number of known chemical substances used intentionally in FCMs exceeds 4000.

Furthermore, potential cellular changes caused by FCMs, and in particular, those with the capacity to disrupt hormones, are not even being considered in routine toxicology analysis, which prompts the authors to suggest that this "casts serious doubts on the adequacy of chemical regulatory procedures."

They admit that establishing potential cause and effect as a result of lifelong and largely invisible exposure to FCMs will be no easy task, largely because there are no unexposed populations to compare with, and there are likely to be wide differences in exposure levels among individuals and across certain population groups.

But some sort of population-based assessment and biomonitoring are urgently needed to tease out any potential links between food contact chemicals and chronic conditions like cancer, obesity, diabetes, neurological and inflammatory disorders, particularly given the known role of environmental pollutants, they argue.

"Since most foods are packaged, and the entire population is likely to be exposed, it is of utmost importance that gaps in knowledge are reliably and rapidly filled," they urge.

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Study Finds Widespread Exposure to Chemical Plastic Softeners Despite Partial Ban

Americans are being exposed to significantly lower levels of some phthalates that were banned from children’s articles in 2008, but exposures to other forms of these chemicals are rising steeply, according to a study led by researchers at UC San Francisco.

Phthalates, which are used to soften plastic, can be found in nail polish, fragrances, plastics and building materials, as well as the food supply. An accumulating body of scientific evidence suggests they can disrupt the endocrine system, which secretes hormones, and may have serious long-term health consequences.

Phthalate exposures to adult men have been linked to DNA damage in sperm and lower sperm quality, while exposures to pregnant women have been linked to alterations in the genital development of their male children, as well as cognitive and behavioral problems in boys and girls.

The paper, published in Environmental Health Perspectives, is the first to examine how phthalate exposures have changed over time in a large, representative sample of the U.S. population. It delineates trends in a decade’s worth of data—from 2001 to 2010—in exposure to eight phthalates among 11,000 people who took part in the National Health and Nutrition Examination Survey conducted by the U.S. Centers for Disease Control and Prevention.

“We were excited to see that exposure to some of the phthalates that are of public health concern actually went down,” said Ami Zota, ScD, MS, an assistant professor of environmental and occupational health at the George Washington University School of Public Health and Health Services, who did the research when she was a postdoctoral fellow at UCSF’s Program on Reproductive Health and the Environment. “Unfortunately, our data also suggest that these are being replaced by other phthalates with potential adverse health effects.”

Like previous studies, this one found that nearly all of the study participants had been exposed to at least some of the phthalates that were measured, including those that have been partially banned. Six of the phthalates have been banned from use in children’s articles, such as toys. Three were permanently banned, and three were subject to an interim ban, pending further study, from use in toys that can be placed in a child’s mouth. The law took effect in January of 2009.

Exposures went up in the phthalates that Congress banned pending further study. They increased by 15 and 25 percent in the first two, but went up nearly 150 percent in DiNP, which industry is using to replace other phthalates. DiNP was recently added to the list of chemicals known by the state of California to cause cancer under California’s Proposition 65.

Fetal BPA exposure increases risk of prostate cancer later in life

Fetal exposure to a commonly used chemical found in products such as water bottles, soup can liners and paper receipts can increase the risk for prostate cancer later in life, according to a study from the University of Illinois at Chicago.

Bisphenol A, or BPA, is widely used to soften plastics. Steering clear of the chemical is nearly impossible, says Gail Prins, professor of physiology at UIC and lead author of the paper.

“Previous studies have shown that people who avoided all contact with plastics or other BPA-containing objects for up to a month or more still had BPA in their urine, which means they must have come into contact with BPA in the last 24 to 48 hours, since it clears the body rather quickly,” said Prins, who is director of the UIC andrology laboratory. “It’s very hard to avoid.”

Exposure of the fetus to BPA in utero is of particular concern, because the chemical, which mimics the hormone estrogen, has been linked to several kinds of cancer, including prostate cancer, in rodent models. The new findings show that human prostate tissue is also susceptible.

“Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue,” Prins said. “The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food and Drug Administration to re-evaluate their policies in the near future.”

Prins investigated the effect of BPA on human cells by implanting human prostate stem cells taken from deceased young-adult men into mice. Prostate stem cells are very long-lived. They arise during early fetal development and produce and maintain a man’s prostate tissue throughout his life.

To mimic exposure to BPA during embryonic development, for two weeks following implantation the mice were fed BPA — in amounts in line with those seen in pregnant American women — as the cells produced humanized prostate tissue.

“The amount of BPA we fed the mice was equivalent to levels ingested by the average person,” Prins said. “We didn’t feed them exorbitantly high doses.”

After the tissue was allowed to mature for one month, the mice were given estrogen to mimic the naturally rising estrogen levels seen in aging men. This rise in estrogen later in life is one of the known drivers of prostate cancer.

Tissue was collected after two to four months and analyzed for prostate disease. Prins found that a third of tissue samples taken from mice fed BPA had either pre-cancerous lesions or prostate cancer, compared to only 12 percent in a control group of mice fed oil. If the prostate stem cells were exposed to BPA before implantation and again as they produced prostate tissue in the mice, 45 percent of the tissue samples had pre-cancerous lesions or cancer.

“We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer,” Prins said.

The study was published in the journal Endocrinology.

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PCBs still affecting our health decades later

Although PCBs have been banned in the United States since 1979, University of Montreal and CHU Sainte-Justine researcher Maryse Bouchard has found that higher levels of the toxin was associated with lower cognitive performance in seniors.

There is a significant association between PCB levels and cognitive abilities among individuals aged 70 to 84 years; the correlation was also detected to a lesser extent among people aged 60-69 years. This analysis also showed that the association differed by sex. Women in the older age group had the largest diminution in cognition in relation to exposure. "While most studies have looked at the impact of PCBs on infant development, our research shows that this toxin might affect us throughout our lives," Bouchard said.

The use and production of PCBs have been phased out for over 40 years, but these highly persistent substances are still found in the blood of most individuals, especially older people. 708 Americans participated in Bouchard's study, which involved providing blood samples to determine the levels of toxins in their bodies and completing a memory and motor-skill task to determine their cognitive performance. The PCB levels found in their bodies were representative of those in the general U.S population. "Aging persons could be at particular risk because of higher cumulative exposure built up across a lifetime, susceptibility due to underlying medical conditions, such as vascular disorders, and diminished cognitive reserve capacity," Bouchard said. "Our present findings suggest that PCBs, even at levels generally considered to pose low or no risk, may contribute to cognitive deficits."

PCB disposal processes currently range from effective remediation to deliberate dumping. They accumulate in the lipid tissues of animal and marine life forms, and biomagnify across the food chain. As a result, PCBs are today ubiquitously present in tissues of human populations, in North American and around the world. This study underscores the importance of improving our response to PCBs as a health hazard.

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Heavy air pollution, male cancer spikes found downwind of “Industrial Heartland”

Isobel Simpson / UC Irvine

Levels of contaminants higher than in some of the world’s most polluted cities have been found downwind of Canada’s largest oil, gas and tar sands processing zone, in a rural area where men suffer elevated rates of cancers linked to such chemicals.

The findings by UC Irvine and University of Michigan scientists, published online this week, reveal high levels of the carcinogens 1,3-butadiene and benzene and other airborne pollutants. The researchers also obtained health records spanning more than a decade that showed the number of men with leukemia and non-Hodgkin’s lymphoma was greater in communities closest to the pollution plumes than in neighboring counties. The work is a dramatic illustration of a new World Health Organization report that outdoor air pollution is a leading cause of cancer.

While the scientists stopped short of saying that the pollutants they documented were definitely causing the male cancers, they strongly recommended that the industrial emissions be decreased to protect both workers and nearby residents.

“Our study was designed to test what kinds of concentrations could be encountered on the ground during a random visit downwind of various facilities. We’re seeing elevated levels of carcinogens and other gases in the same area where we’re seeing excess cancers known to be caused by these chemicals,” said UC Irvine chemist Isobel Simpson, lead author of the paper in Atmospheric Environment. “Our main point is that it would be good to proactively lower these emissions of known carcinogens. You can study it and study it, but at some point you just have to say, ‘Let’s reduce it.’ ”

Co-author Stuart Batterman, a University of Michigan professor of environmental health sciences, agreed: “These levels, found over a broad area, are clearly associated with industrial emissions. They also are evidence of major regulatory gaps in monitoring and controlling such emissions and in public health surveillance.”

The researchers captured emissions in the rural Fort Saskatchewan area downwind of major refineries, chemical manufacturers and tar sands processors owned by BP, Dow, Shell and other companies in the so-called “Industrial Heartland” of Alberta. They took one-minute samples at random times in 2008, 2010 and 2012. All showed similar results. Amounts of some dangerous volatile organic compounds were 6,000 times higher than normal.

The team compared the Alberta plumes to heavily polluted megacities. To their surprise, the scientists saw that levels of some chemicals were higher than in Mexico City during the 1990s or in the still polluted Houston-Galveston area.

Simpson is part of UC Irvine’s Blake-Rowland Group, which has measured air pollution around the world for decades. She and Batterman said the findings were important for other residential areas downwind of refineries and chemical manufacturers, including parts of Los Angeles.

“For any community downwind of heavy industrial activity, I would say it’s certainly prudent to conduct surveys of both air quality – especially carcinogens – and human health,” Simpson said.

“For decades, we’ve known that exposure to outdoor air pollutants can cause respiratory and cardiovascular disease,” Batterman said. “The World Health Organization has now also formally recognized that outdoor air pollution is a leading environmental cause of cancer deaths.”

Longtime residents near industrial Alberta have struggled to bring attention to bad odors, health threats and related concerns. The peer-reviewed study is one of few in the region and more investigation of the large and complex facilities is needed.

Air purifiers for industrial pollution

For example, Simpson said, it appeared in some cases that the companies were not reporting all of the tons of chemicals they release. She and her colleagues documented high levels of 1,3-butadiene that could only have come from one facility, but she said the company had not reported any such emissions.

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Deep sea ecosystem may take decades to recover from Deepwater Horizon spill

Multicorer sampling in the Gulf of Mexico

The deep-sea soft-sediment in the immediate area of the 2010 Deepwater Horizon oil spill in the Gulf of Mexico will likely take decades to recover from the spill's impacts, according to a scientific paper reported in the online scientific journal PLoS One.

The paper is the first to give comprehensive results of the spill's effect on deep-water communities at the base of the Gulf's food chain, in its soft-bottom muddy habitats, specifically looking at biological composition and chemicals at the same time at the same location.

"As the principal investigators, we were tasked with determining what impacts might have occurred to the sea floor from the Deepwater Horizon oil spill," said Paul Montagna, Ph.D., Endowed Chair for Ecosystems and Modeling at the Harte Research Institute for Gulf of Mexico Studies, Texas A&M University-Corpus Christi. "We developed an innovative approach to combine tried and true classical statistical techniques with state of the art mapping technologies to create a map of the footprint of the oil spill."

"Normally, when we investigate offshore drilling sites, we find pollution within 300 to 600 yards from the site," said Montagna. "This time it was nearly two miles from the wellhead, with identifiable impacts more than ten miles away. The effect on bottom of the vast underwater plume is something, which until now, no one was able to map. This study shows the devastating effect the spill had on the sea floor itself, and demonstrates the damage to important natural resources."

"The tremendous biodiversity of meiofauna in the deep-sea area of the Gulf of Mexico we studied has been reduced dramatically," said Jeff Baguley, Ph.D., University of Nevada, Reno expert on meiofauna, small invertebrates that range in size from 0.042 to 0.300 millimeters in size that live in both marine and fresh water. "Nematode worms have become the dominant species at sites we sampled that were impacted by the oil. So though the overall number of meiofauna may not have changed much, it's that we've lost the incredible biodiversity."

The oil spill and plume covered almost 360 square miles with the most severe reduction of biological abundance and biodiversity impacting an area about 9 square miles around the wellhead, and moderate effects seen 57 square miles around the wellhead.

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Experts Say Endocrine-Disrupting Chemicals Pose Global Health Threat

In an editorial published in Endocrinology, a journal of The Endocrine Society, endocrine experts agreed that endocrine-disrupting chemicals (EDCs) pose a threat to human health and to the ecosystems of the earth. The editorial comes in response to a commentary (Dietrich et al. Chem Biol Interact) signed by a number of editors of toxicology journals that dismisses the state-of-the-science on EDCs and argues for the status quo in the regulation of these hazardous substances.

EDCs are commonly found in food and food containers, plastic products, furniture, toys, carpeting, building materials, and cosmetics. They are often released from the products that contain them and enter the bodies of humans and wildlife through dust or through the food chain. A large volume of studies have shown that EDCs exert their effects by interfering with endogenous hormone action and can impact male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology.

“The Dietrich et al. paper neglects the fundamental principles of how the endocrine system works and how chemicals can interfere with its normal function, nor does it consider the consequences of that interference,” said Andrea Gore, PhD, lead author of the editorial and Editor-in-Chief of Endocrinology. “We cannot have sound policies for regulating these chemicals when we ignore the science.”

The Endocrinology editorial, Gore et al., represents an unprecedented response from the endocrine community. The editorial was signed by 20 editors-in-chief and 28 associate and senior editors of endocrine, neuroendocrine, environmental, and other peer-reviewed journals. Dr. Teresa Woodruff, PhD, President of The Endocrine Society and several other presidents of societies or medical organizations have also signed on to the editorial.

The Endocrine Society has published a Scientific Statement on EDCs—a thorough review of the literature, with recommendations for improved policy—and a Statement of Principles—a summary of critical endocrine principles that are relevant to risk assessment as it applies to EDCs. In its Statement of Principles, the Society recommends that endocrine principles be incorporated into programs by the EPA and other agencies charged with evaluating chemicals for endocrine-disrupting potential.

“Regulatory decisions on the use of EDCs should be made based on the best available science and expertise that involves among others, reproductive biology, endocrinology, medicine, genetics and toxicology,” said Gore.

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Study: Gulf oil spill cleanup workers show blood abnormalities

A new study reports that workers exposed to crude oil and dispersants used during the Gulf oil spill cleanup display significantly altered blood profiles, liver enzymes, and somatic symptoms compared to an unexposed control group. Investigators found that platelet counts were significantly decreased in the exposed group, while both hemoglobin and hematocrit levels were notably increased. Their findings, reported in The American Journal of Medicine, suggest that oil spill cleanup workers are at risk for developing hepatic or blood-related disorders.

In April 2010, Deepwater Horizon, an offshore drilling rig owned by British Petroleum (BP) exploded, spewing over 200 million gallons of oil into the Gulf of Mexico. In order to break down the oil slick, BP used nearly 2 million gallons of dispersants like COREXIT, and an estimated 170,000 workers participated in the cleanup effort. Currently, COREXIT is banned in the United Kingdom because of its potential risk to cleanup workers.

While other studies have identified a relationship between oil spills, dispersants, and human health, this new research from the University Cancer and Diagnostic Centers, Houston, TX, conducted by Mark A. D’Andrea, MD, FACRO, and G. Kesava Reddy, PhD, MHA, focuses primarily on the link between oil spill exposure and hematologic and hepatic functions in subjects who had participated in the oil spill cleanup operation. The investigators looked at a total of 247 subjects between January 2010 and November 2012, with 117 subjects identified as exposed to the oil spill and dispersants by participating in the cleanup over the duration of three months. The unexposed control group of 130 subjects was comprised of people living at least 100 miles away from the Gulf coast of Louisiana.

Using medical charts, demographic and clinical records, the team reviewed specific data points such as white blood cell (WBC) counts, platelet counts, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, serum beta-2 microglobulin, alkaline phosphatase (ALP), aspartate amino transferase (AST), and alanine amino transferase (ALT) for both groups.

While no significant differences were noted in the WBC counts of the two groups, the study did find that platelet counts were notably decreased in the oil spill exposed group. Also, BUN and creatinine levels were substantially lower in the exposed group, while hemoglobin and hematocrit levels were increased compared to the unexposed subjects. Furthermore, considered indicators of hepatic damage, the serum ALP, AST, and ALT levels in the exposed subjects were also elevated, suggesting that the exposed group may be at a higher risk for developing blood-related disorders.

"Phosphatases, amino transferases, and dehydrogenases play critical roles in biological processes. These enzymes are involved in detoxification, metabolism, and biosynthesis of energetic macromolecules that are important for different essential functions," says lead investigator Dr. Mark A. D’Andrea. "Alterations in the levels of these enzymes result in biochemical impairment and lesions in the tissue and cellular function."

Participants also reported somatic symptoms, with headache reported most frequently, followed by shortness of breath, skin rash, cough, dizzy spells, fatigue, painful joints, night sweats, and chest pain. "The health complaints reported by those involved in oil cleanup operations are consistent with the previously reported studies on major oil spills. However, the prevalence of symptoms appears to be higher in the present study compared with the earlier findings of other investigators," add Dr. D’Andrea and Dr. Reddy.

The investigators acknowledge that the lack of pre-disaster health data on the subjects involved in the study is the greatest limiting factor; however, the data collected have shown significant health effects on the cleanup workers.

"To our knowledge, no previous study has explored the effects of the oil spill specifically assessing the hematological and hepatic functions in oil spill cleanup workers," explain the investigators. "The results of this study indicate that oil spill exposure appears to play a role in the development of hematologic and hepatic toxicity. However, additional long-term follow-up studies are required to understand the clinical significance of the oil spill exposure."

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Lifelong exposure to low levels of pollution may have long-term health consequences

If you're eating better and exercising regularly, but still aren't seeing improvements in your health, there might be a reason: pollution. According to a new research report published in the September issue of The FASEB Journal, what you are eating and doing may not be the problem, but what's in what you are eating could be the culprit.

"This study adds evidences for rethinking the way of addressing risk assessment especially when considering that the human population is widely exposed to low levels of thousands of chemicals, and that the health impact of realistic mixtures of pollutants will have to be tested as well," said Brigitte Le Magueresse-Battistoni, a researcher involved in the work from the French National Institute of Health and Medical Research (INSERM).

"Indeed, one pollutant could have a different effect when in mixture with other pollutants. Thus, our study may have strong implications in terms of recommendations for food security. Our data also bring new light to the understanding of the impact of environmental food contaminants in the development of metabolic diseases."

To make this discovery, scientists used two groups of obese mice. Both were fed a high-fat, high-sucrose enriched diet, with one group receiving a cocktail of pollutants added to its diet at a very low dosage. These pollutants were given to the mice throughout—from pre-conception to adulthood. Although the researchers did not observe toxicity or excess of weight gain in the group having received the cocktail of pollutants, they did see a deterioration of glucose tolerance in females, suggesting a defect in insulin signaling. Study results suggest that the mixture of pollutants reduced estrogen activity in the liver through enhancing an enzyme in charge of estrogen elimination. In contrast to females, glucose tolerance was not impacted in males exposed to the cocktail of pollutants. However, males did show some changes in liver related to cholesterol synthesis and transport. This study fuels the concept that pollutants may contribute to the current prevalence of chronic diseases including metabolic diseases and diabetes.

"This report that confirms something we've known for a long time: pollution is bad for us," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "But, what's equally important, it shows that evaluating food contaminants and pollutants on an individual basis may be too simplistic. We can see that when "safe" levels of contaminants and pollutants act together, they have significant impact on public health."

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Video: Impacts of chemicals on the young brain; presentation

Professor Deborah Cory-Slechta of the University of Rochester School of Medicine shows how environmental contaminants such as lead and mercury and social stressors share the same pathways to causing neurodevelopmental effects on children's brains and learning abilities.



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BPA exposure disrupts human egg maturation; may explain some fertility problems

		IMAGE: Images of eggs examined in this study show a properly formed spindle structure with aligned chromosomes (image A) and eggs with spindles of various abnormal shapes and misaligned chromosomes after... Click here for more information.

As many as 20 percent of infertile couples in the United States have unexplained reasons for their infertility. Now, new research led by Catherine Racowsky, PhD, director of the Assisted Reproductive Technologies Laboratory at Brigham and Women's Hospital (BWH), shows that exposure to BPA (Bisphenol-A) could be a contributing factor as to why some infertile couples are having difficulty conceiving. The study will be published online on July 31, 2013 in the journal Human Reproduction.

"To our knowledge, this is the first study that has shown that BPA has a direct effect on egg maturation in humans," said Dr. Racowsky. "Because exposure to BPA is so ubiquitous, patients and medical professionals should be aware that BPA may cause a significant disruption to the fundamentals of the human reproductive process and may play a role in unexplained infertility."

The randomized trial examined 352 eggs from 121 consenting patients at a fertility clinic. The eggs, which would have otherwise been discarded, were exposed to varying levels (20 ng/ml, 200 ng/ml and 20 µg/ml) of BPA in a laboratory setting. An egg from each patient was not exposed to BPA and served as the control. Researchers then examined the eggs and found that exposure to BPA caused:

• A decrease in the percentage of eggs that matured.
• An increase in the percentage of eggs that degenerated.
• An increase in the percentage of eggs that underwent spontaneous activation, the abnormal process when an egg acts as though it has been fertilized, even though it has not been.

As the BPA dose increased, there was a decreased likelihood of maturity, an increased likelihood of degeneration and an increased likelihood of spontaneous activation. Additionally, among the mature eggs, there was a significant trend toward a decreased incidence of bipolar spindles and aligned chromosomes with an increased dose of BPA. Researchers note that these results are similar to the previous research examining the impact of BPA exposure on animal eggs.

Racowsky said, "Our data show that BPA exposure can dramatically inhibit egg maturation and adds to a growing body of evidence about the impact of BPA on human health. I would encourage further research to gain a greater understanding of the role BPA plays in infertility."

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Pedticides not contained on farmland; Scientists find contaminated frogs far from fields

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Pesticides commonly used in California's Central Valley, one of the world's most productive agricultural regions, have been found in remote frog species miles from farmland. Writing in Environmental Toxicology and Chemistry, researchers demonstrate the contamination of Pacific Tree Fogs in remote mountain areas, including national parks; supporting past research on the potential transport of pesticides by the elements.

California's Central Valley is one of the most intensely farmed regions in North America, producing 8% of U.S agricultural output by value. While the use of pesticides such as triazines, endosulfan and organophosphates is common across the U.S., California uses more pesticides than any other state.

"Our results show that current-use pesticides, particularly fungicides, are accumulating in the bodies of Pacific chorus frogs in the Sierra Nevada," said Kelly Smalling a research hydrologist from the U.S. Geological Survey. "This is the first time we've detected many of these compounds, including fungicides, in these remote locations."

The Pacific chorus frog Pseudacris Regilla can be found in abundance across the state's Sierra Nevada mountain range. As with other amphibians, agrochemicals potentially pose a threat to chorus frogs, as exposure to pesticides can decrease their immune system, thereby increasing the risk of disease.

The team collected frogs, as well as water and sediment samples, from seven ponds ranging from Lassen Volcanic National Park at the northern most point of Central Valley, to the Giant Sequoia National Monument in the valley's southern extent. All sites were downwind of agricultural areas.

"The samples were tested for 98 types of pesticides, traces of which were found in frog tissues from all sites," said Smalling. "We found that even frogs living in the most remote mountain locations were contaminated by agricultural pesticides, transported long distances in dust and by rain."

Two fungicides, commonly used in agriculture, pyraclostrobin and tebuconazole, and one herbicide, simazine, were the most frequently detected compounds, and this is the first time these compounds have ever been reported in wild frog tissue. Another commonly detected pesticide was DDE (Dichlorodiphenyldichloroethylene) a breakdown product of DDT which was banned in the United States in 1972. The continued presence of a DDT byproduct reveals how long this banned chemical can impact biodiversity.

A comparison of the frog tissue with water and sediment collected from the same sites shows that the frogs were the more reliable indicator of chemical exposure. This is partly due to the physical-chemical properties of the l compounds and biological influences such as such as organism specific metabolism and life history. Documenting the occurrence of these compounds is an important first step in figuring out the health consequence associated with the exposures.

"Very few studies have considered the environmental occurrence of pesticides, particularly fungicides which can be transported beyond farmland," concluded Smalling. "Our evidence raises new challenges for resource managers; demonstrating the need to keep track of continual changes in pesticides use and to determine potential routes of exposure in the wild."

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Lower intelligence, hyperactivity seen in kids whose mothers were exposed to the chemicals

Chemicals called polybrominated diphenyl ethers (PBDEs) have been used for decades to reduce fires in everyday products such as baby strollers, carpeting and electronics. A new study to be presented on Monday, May 6, at the Pediatric Academic Societies (PAS) annual meeting shows that prenatal exposure to the flame retardants is associated with lower intelligence and hyperactivity in early childhood.

"In animal studies, PBDEs can disrupt thyroid hormone and cause hyperactivity and learning problems," said lead author Aimin Chen, MD, PhD, assistant professor in the Department of Environmental Health at University of Cincinnati College of Medicine. "Our study adds to several other human studies to highlight the need to reduce exposure to PBDEs in pregnant women."

Dr. Chen and his colleagues collected blood samples from 309 pregnant women enrolled in a study at Cincinnati Children's Hospital Medical Center to measure PBDE levels. They also performed intelligence and behavior tests on the women's children annually until they were 5 years old.

"We found maternal exposure to PBDEs, a group of brominated flame retardants mostly withdrawn from the U.S. market in 2004, was associated with deficits in child cognition at age 5 years and hyperactivity at ages 2-5 years," Dr. Chen said. A 10-fold increase in maternal PBDEs was associated with about a 4 point IQ deficit in 5-year-old children.

Even though PBDEs, except Deca-BDEs, are not used as a flame retardant in the United States anymore, they are found on many consumer products bought several years ago. In addition, the chemicals are not easily biodegradable, so they remain in human tissues and are transferred to the developing fetus.

"Because PBDEs exist in the home and office environment as they are contained in old furniture, carpet pads, foams and electronics, the study raises further concern about their toxicity in developing children," Dr. Chen concluded.

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Scientists Urge UN to Take Action on Chemicals in Consumer Products and Pesticides

A group of influential scientists have called for swift action by the UN to prevent harm from a wide variety of synthetic chemicals in consumer products and pesticides that play a role in increased incidences of reproductive diseases, cancer, obesity, and type-2 diabetes worldwide.

The scientists include authors of a recent report by the World Health Organization (WHO) and the United Nations Environment Program (UNEP), which underlines the urgent need for global action to address the dangers of hormone or endocrine disrupting chemicals (EDCs).

The scientists’ statement is part of a growing international effort to identify and control the harmful effects of chemicals that damage hormonal (endocrine) systems in humans and wildlife that is supported by more than 100 countries engaged in a process to develop a global plan for the safe management of chemicals.

“Exposure to EDCs during fetal development and puberty plays a role in the increased incidences of reproductive disease, endocrine-related cancers, behavioral and learning problems including ADHD, infections, asthma and perhaps obesity and diabetes in humans,” said William F. Young, Jr., MD, president of The Endocrine Society, the most active organization devoted to research on hormones and the clinical practice of endocrinology. The Society’s 2009 Scientific Statement on EDCs was the first in-depth scientific report to draw attention to the unique properties of these chemicals, and the Society and its members remain active in advancing endocrine science and the knowledge of how EDCs affect health.

EDCs are commonly found in food and food containers, plastic products, furniture, toys, carpeting, building materials, and cosmetics. EDCs include chemicals such as bisphenol A (water bottles, can linings), certain phthalates (various plastic products and cosmetics), and pesticides such as chlorpyrifos (used on a wide variety of food crops). They are often released from the products that contain them and enter the bodies of humans and wildlife through dust or through the food chain. Tests show the presence of dozens of chemicals with hormone disrupting properties in people, including developing children. Manufacturers of suspected EDCs include some of the world’s largest chemical manufacturers, such as Exxon Mobil, Dow, DuPont, BASF, Monsanto, Eastman Chemical, and others.

In their letter addressed to UNEP, WHO, Organization for Economic Cooperation and Development (OECD) and the Strategic Approach to International Chemicals Management (SAICM), the scientists recommended a number of key principles, supported by current scientific research, to guide upcoming efforts in this area.

A clear definition of EDCs. Endocrine disrupting chemicals are chemicals, or chemical mixtures, that interfere with normal hormone action.

Vulnerability of living organisms. Hormones and their signaling pathways are critical for normal functioning in all vertebrates and invertebrates.

EDCs effects occur at low doses. Many EDC effects occur at low doses even when high dose effects are not apparent.

EDCs can affect future generations and timing of exposure is key. The most sensitive period is during periods of development, from the fetal and post-natal periods, which can extend into infancy and childhood for some tissues.

Exposure to EDC mixtures may be different than exposure to single substances. Humans and animals are exposed to complex mixtures of hundreds of EDCs.

The Precautionary Principle is key. Decision-making should err on the side of precaution.
“EDCs present unacceptable risks to human health and the environment, and that is why more than 100 governments reached consensus agreement that action is needed,” said Olga Speranskaya, co-chair, IPEN. “In our letter, we outline the most important principles for actions on EDCs. We urge the international agencies to utilize these principles as the basis for moving forward as quickly as possible.”

A recent report from WHO and UNEP, State of the Science of Endocrine Disrupting Chemicals, 2012, said that recent increases in the incidence of endocrine-related diseases in people and wildlife cannot be explained by genetics alone and that EDCs are a “global threat that needs to be resolved.” A recent editorial in Environmental Health Perspectives, a leading, peer-reviewed journal, identified EDCs as a global problem requiring global solutions. And more than 100 countries participating in an international process for implementing a global safe chemicals management plan (SAICM) reached consensus agreement that EDCs are an emerging issue requiring capacity building and awareness-raising and the translation of research results into control actions.

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Study Shows Reproductive Effects of Pesticide Exposure Span Generations

Photo: freedigitalphotos.net

North Carolina State University researchers studying aquatic organisms called Daphnia have found that exposure to a chemical pesticide has impacts that span multiple generations – causing the so-called “water fleas” to produce more male offspring, and causing reproductive problems in female offspring.

“This work supports the hypothesis that exposure to some environmental chemicals during sensitive periods of development can cause significant health problems for those organisms later in life – and affect their offspring and, possibly, their offspring’s offspring,” says Dr. Gerald LeBlanc, a professor of environmental and molecular toxicology at NC State and lead author of a paper on the work. “We were looking at a model organism, identified an important pathway for environmental sex determination, and found that there are chemicals that can hijack that pathway.”

Environmental cues normally determine the sex, male or female, of Daphnia offspring, and researchers have been working to understand the mechanisms involved. As part of that work, LeBlanc’s team had previously identified a hormone called methyl farnesoate (Mf) that Daphnia produce under certain environmental conditions.

The researchers have now found that the hormone binds with a protein receptor called the Mf receptor, which can regulate gene transcription and appears to be tied to the production of male offspring.

In experiments, the researchers exposed Daphnia to varying levels of an insecticide called pyriproxyfen, which mimics the Mf hormone. The pyriproxyfen exposure resulted in Daphnia producing more male offspring and fewer offspring in total, with higher doses exacerbating both effects.

“At high concentrations, we were getting only male offspring, which is not good,” LeBlanc says. “Producing fewer offspring, specifically fewer female offspring, could significantly limit population numbers for Daphnia.”

And low exposure concentrations had significant impacts as well. At pyriproxyfen concentrations as low as 71 nanograms per liter, or 71 parts per trillion, the Daphnia would still produce some female offspring. But those females suffered long-term reproductive health effects, producing significantly smaller numbers of offspring – despite the fact that they had not been exposed to pyriproxyfen since birth.

“We now want to know specifically which genes are involved in this sex determination process,” LeBlanc says. “And, ecologically, it would be important to know the impact of changes in population dynamics for this species. Daphnia are a keystone species – an important food source for juvenile fish and other organisms.”

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High Levels of Lead Found in Imported Rice and Baby Food

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Rice imported from certain countries contains high levels of lead that could pose health risks, particularly for infants and children, who are especially sensitive to lead’s effects, and adults of Asian heritage who consume large amounts of rice, scientists said here today. Their research, which found some of the highest lead levels in baby food, was among almost 12,000 reports scheduled for the 245th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society, which continues through Thursday.

Tsanangurayi Tongesayi, Ph.D., who headed the analysis of rice imported from Asia, Europe and South America, pointed out that imports account for only 7 percent of the rice consumed in the United States. With vast rice fields in Louisiana, California, Texas, Arkansas and Mississippi, the U.S. is a major producer and exporter of the grain. However, imports of rice and rice flour are increasing ― by more than 200 percent since 1999 ― and rice is the staple food for 3 billion people worldwide, he added.
“Such findings present a situation that is particularly worrisome given that infants and children are especially vulnerable to the effects of lead poisoning,” Tongesayi said. “For infants and children, the daily exposure levels from eating the rice products analyzed in this study would be 30-60 times higher than the FDA’s provisional total tolerable intake (PTTI) levels. Asians consume more rice, and for these infants and children, exposures would be 60-120 times higher. For adults, the daily exposure levels were 20-40 times higher than the PTTI levels.”

The research was part of a symposium titled “Food and Its Environment: What Is In What We Eat?”

Tongesayi’s team, which is with Monmouth University in N.J., found that levels of lead in rice imported into the United States ranged from 6 to 12 milligrams/kilogram. From those numbers, they calculated the daily exposure levels for various populations and then made comparisons with the FDA’s PTTI levels for lead. They detected the highest amounts of lead in rice from Taiwan and China. Samples from the Czech Republic, Bhutan, Italy, India and Thailand had significantly high levels of lead as well. Analysis of rice samples from Pakistan, Brazil and other countries were still underway.

Because of the increase in rice imports into the United States, Tongesayi said that rice from other nations has made its way into a wide variety of grocery stores, large supermarket chains and restaurants, as well as ethnic specialty markets and restaurants.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.
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Combinations of estrogen-mimicking chemicals found to strongly distort hormone action

For years, scientists have been concerned about chemicals in the environment that mimic the estrogens found in the body. In study after study, researchers have found links between these "xenoestrogens" and such problems as decreased sperm viability, ovarian dysfunction, neurodevelopmental deficits and obesity. But experimental limitations have prevented them from exploring one of the most serious questions posed by exposure to xenoestrogens: what happens when — as in the real world — an individual is exposed to multiple estrogen-mimicking chemicals at the same time?

Now University of Texas Medical Branch at Galveston researchers have used new techniques to study exposure to low doses of multiple xenoestrogens. And they've come to some disturbing conclusions.

Using cell cultures to test mixtures of three compounds known to affect estrogen signaling, — bisphenol A (found in plastic bottles and the linings), bisphenol S (a supposedly safer replacement for bisphenol A recently found to have similar effects) and nonylphenol (a common component of industrial detergents and surfactants) — the scientists determined that combinations of endocrine disruptors could have a dramatically greater effect than any one of them alone.

"We wanted to see how these persistent, ubiquitous contaminants affect estrogenic signaling when they're mixed together as they are in nature, so we set up a cell-culture system that allowed us to test their influence on signaling by estradiol, the estrogen found in adult, cycling women," said UTMB professor Cheryl Watson, senior author of a paper on the study now online in the journal Environmental Health (http://www.ehjournal.net/). "What we found is that these things gang up on estradiol and thwart its response, which is not a good thing."

Watson and her colleagues tested different mixtures of estrogen-disrupting compounds using rat pituitary cells, cells that are master regulators of the animals' endocrine systems. Their experiments measured the responses of key signaling pathways that lead to cell proliferation, the secretion of the pituitary hormone prolactin and the activation of proteins involved in apoptosis (programmed cell death), comparing the effects of estradiol alone with those of estradiol and mixtures of bisphenol A, bisphenol S and nonylphenol.

"These compounds work at very low concentrations — at the parts per trillion or parts per quadrillion level — and when you mix them together they affect estrogenic signaling differently and more dramatically than they do individually," Watson said. "We need to pay attention to this, because estrogens influence so many things in both males and females — reproduction, the immune system, metabolism, bone growth, all sorts of important biological functions."

Studies have detected measurable levels of bisphenol A and bisphenol S in the urine of more than 90 percent of Americans. According to Watson, modern humans are exposed to dozens of xenoestrogens more or less continually.

"These things are all over the environment, and we need to know what they do so we can start figuring out what we need to change," Watson said. "They're probably disrupting and confusing hormones in people, and it's important to find a way to prevent that as soon as we can. We need to test these compounds for their hormone-disrupting activities before they are put into products, so we can redesign for safety very early in the process."