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California researchers have now
linked a third type of pesticide, ziram with Parkinson's disease.
In a follow-up study to their 2009
findings, the UCLA scientists studied not only people who lived and worked in or near fields that were
sprayed, but non-farmworkers like teachers, firefighters and clerks who worked near the fields.
They found that the combined
exposure to ziram, maneb and paraquat near any workplace increased the risk of
Parkinson's disease (PD) threefold, while combined exposure to ziram and
paraquat alone was associated with an 80 percent increase in risk. The results
appear in the current online edition of the European Journal of Epidemiology.
"Our estimates of risk for
ambient exposure in the workplaces were actually greater than for exposure at
residences," said Dr. Beate Ritz, senior author and a professor of
epidemiology at the UCLA School of Public Health. "And, of course, people
who both live and work near these fields experience the greatest risk. These
workplace results give us independent confirmation of our earlier work that
focused only on residences, and of the damage these chemicals are doing."
In addition, Ritz noted, this
is the first study that provides strong evidence in humans that the combination
of the three chemicals confers a greater risk of Parkinson's than exposure to
the individual chemicals alone. Because these pesticides affect different
mechanisms leading to cell death, they may act together to increase the risk of
developing the disorder: Those exposed to all three experienced the greatest
increase in risk.
"Our results suggest that
pesticides affecting different cellular mechanisms that contribute to
dopaminergic neuron death may act together to increase the risk of PD
considerably," said Ritz, who holds a joint appointment in the UCLA
Department of Neurology.
Scientists knew that in animal
models and cell cultures, such pesticides trigger a neurodegenerative process
that leads to Parkinson's, a degenerative disorder of the central nervous
system that often impairs motor skills, speech and other functions and for which
there is no cure. The disease has been reported to occur at high
rates among farmers and in rural populations, contributing to the hypothesis
that agricultural pesticides may be partially responsible.
In the past, data on human exposure
had been unavailable, largely because it had been too hard to measure an
individual's environmental exposure to any specific pesticide.
"This stuff drifts," Ritz
said. "It's borne by the wind and can wind up on plants and animals, float
into open doorways or kitchen windows — up to several hundred meters from the
fields."
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